Record goalscorer Aguero continues to build up his fitness in training after a spell out with coronavirus, while playmaker De Bruyne is absent with a hamstring injury.
Defender Nathan Ake also remains on the sidelines with a muscular problem.
Pep Guardiola has a few selection dilemmas up and down the field, with the likes of Phil Foden, Riyad Mahrez, Ferran Torres all competing for starts despite the absence of Aguero and De Bruyne.
Fernandinho could return in midfield to replace Rodri, while Oleksandr Zinchenko may start at left-back – though Aymeric Laporte is also an option.
Man City predicted lineup: Ederson; Cancelo, Stones, Dias, Zinchenko; Bernardo Silva, Fernandinho, Gundogan; Mahrez. Jesus, Sterling
Man City squad from: Ederson, Steffen, Walker, Cancelo, Stones, Dias, Laporte, Garcia, Zinchenko, Mendy, Gundogan, Fernandinho, Rodri, Silva, Sterling, Foden, Torres, Mahrez, Jesus, Gomes, Doyle, Bernabe.
Injury list: Sergio Aguero (recovery from Covid-19), Kevin De Bruyne (hamstring)