Gundogan scored twice against Tottenham to make it eight goals to bring his tally to eight goals in his last seven Premier League games, before being forced off.
Pep Guardiola said after the game that “if he is fit, he’s going to play” but was reportedly not spotted in training on Sunday.
De Bruyne has not featured since January 20 and it is hoped he will return to training this week, though Guardiola is wary of rushing but the influential midfielder.
“I want to be sure, we want to be sure, he wants to be sure that when he comes back it is because he is completely recovered and fit,” Guardiola said.
Elsewhere, Fernandinho continues to struggle with niggles ahead of the midweek game, and Nathan Ake is out with a muscle injury.
Should Gundogan not be fit, Raheem Sterling could come into a more central role, supported by both Phil Foden and Riyad Mahrez.
In midfield, Bernardo Silva and Rodri should start again. Ruben Dias may come back in after being an unused substitute against Tottenham.
Predicted Manchester City XI (4-3-3): Ederson; Cancelo, Stones, Dias, Zinchenko; Bernardo, Rodri, Fernandinho; Foden, Sterling, Mahrez